Press

Organoids are carrying the promise of modeling complex disease phenotypes and serving as a powerful basis for unbiased drug screens, potentially offering a more efficient drug-discovery route. However, unsolved technical bottlenecks of reproducibility and scalability have prevented the discovery of new targets using organoids in screening schemes. Here, we present a method that overcomes these limitations by using deep-learning- driven analysis for phenotypic drug screens...

Study gives clues to the origin of Huntington’s disease, and a new way to find drugs. The first signs of Huntington’s, an inherited disease that slowly deteriorates bodies and minds, don’t typically surface until middle age. ...

With new findings, scientists may be poised to break a long impasse in research on Huntington’s disease, a fatal hereditary disorder for which there is currently no treatment....