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Rumi Scientific

Rumi Scientific's mission is to fast-track the early stage of drug discovery using our predictive models of the human brain for therapeutic success. Many neurodevelopmental diseases do not have treatments due to a lack of a-priori knowledge of the underlying biology. Rumi Scientific's technology is able to model these diseases to help enable the discovery of new targets and drugs, de-risking the current failure-prone cumbersome approach.
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E-mail: info@rumiscientific.com
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Publications

Publications by Ali H. Brivanlou, Robert & Harriet Heilbrunn Professor, Head of Laboratory of Stem Cell Biology and Molecular Embryology. For a comprehensive list of publications, please click here.

  1. Self-Organization of Spatial Patterning in Human Embryonic Stem Cells.

    Deglincerti A, Etoc F, Ozair MZ, Brivanlou AH.

    Curr Top Dev Biol. 2016;116:99-113. doi: 10.1016/bs.ctdb.2015.11.010. Epub 2016 Feb 2. Review.

    PMID: 26970615

  2. Self-organization of the in vitro attached human embryo.

    Deglincerti A, Croft GF, Pietila LN, Zernicka-Goetz M, Siggia ED, Brivanlou AH.

    Nature. 2016 May 12;533(7602):251-4. doi: 10.1038/nature17948. Epub 2016 May 4.

    PMID: 27144363

  3. Self-organization of human embryonic stem cells on micropatterns.

    Deglincerti A, Etoc F, Guerra MC, Martyn I, Metzger J, Ruzo A, Simunovic M, Yoney A, Brivanlou AH, Siggia E, Warmflash A.

    Nat Protoc. 2016 Nov;11(11):2223-2232. doi: 10.1038/nprot.2016.131. Epub 2016 Oct 13.

    PMID: 27735934

  4. A Balance between Secreted Inhibitors and Edge Sensing Controls Gastruloid Self-Organization.

    Etoc F, Metzger J, Ruzo A, Kirst C, Yoney A, Ozair MZ, Brivanlou AH, Siggia ED.

    Dev Cell. 2016 Nov 7;39(3):302-315. doi: 10.1016/j.devcel.2016.09.016. Epub 2016 Oct 13.

    PMID: 27746044

  5. Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells.

    Qi Y, Zhang XJ, Renier N, Wu Z, Atkin T, Sun Z, Ozair MZ, Tchieu J, Zimmer B, Fattahi F, Ganat Y, Azevedo R, Zeltner N, Brivanlou AH, Karayiorgou M, Gogos J, Tomishima M, Tessier-Lavigne M, Shi SH, Studer L.

    Nat Biotechnol. 2017 Feb;35(2):154-163. doi: 10.1038/nbt.3777. Epub 2017 Jan 23.

    PMID: 28112759
  6. Embryoids, organoids and gastruloids: new approaches to understanding embryogenesis.

    Simunovic M, Brivanlou AH.

    Development. 2017 Mar 15;144(6):976-985. doi: 10.1242/dev.143529. Review.

    PMID: 28292844

  7. Role of MicroRNAs in Zygotic Genome Activation: Modulation of mRNA During Embryogenesis.

    Rosa A, Brivanlou AH.

    Methods Mol Biol. 2017;1605:31-43. doi: 10.1007/978-1-4939-6988-3_3. Review.

    PMID: 28456956

  8. At Last: Gene Editing in Human Embryos to Understand Human Development.

    Ruzo A, Brivanlou AH.

    Cell Stem Cell. 2017 Nov 2;21(5):564-565. doi: 10.1016/j.stem.2017.10.008.

    PMID: 29100008

  9. Chromosomal instability during neurogenesis in Huntington's disease.

    Ruzo A, Croft GF, Metzger JJ, Galgoczi S, Gerber LJ, Pellegrini C, Wang H Jr, Fenner M, Tse S, Marks A, Nchako C, Brivanlou AH.

    Development. 2018 Jan 29;145(2). pii: dev156844. doi: 10.1242/dev.156844.

    PMID: 29378824

  10. Self-organization of a human organizer by combined Wnt and Nodal signalling.

    Martyn I, Kanno TY, Ruzo A, Siggia ED, Brivanlou AH.

    Nature. 2018 Jun;558(7708):132-135. doi: 10.1038/s41586-018-0150-y. Epub 2018 May 23. Erratum in: Nature. 2018 Dec;564(7735):E10.

    PMID: 29795348

  11. Preface.

    Brivanlou AH.

    Curr Top Dev Biol. 2018;129:xi-xiii. doi: 10.1016/S0070-2153(18)30058-9. No abstract available.

    PMID: 29801533

  12. hPSC Modeling Reveals that Fate Selection of Cortical Deep Projection Neurons Occurs in the Subplate.

    Ozair MZ, Kirst C, van den Berg BL, Ruzo A, Rito T, Brivanlou AH.

    Cell Stem Cell. 2018 Jul 5;23(1):60-73.e6. doi: 10.1016/j.stem.2018.05.024. Epub 2018 Jun 21.

    PMID: 29937203

  13. Synthetic embryology: controlling geometry to model early mammalian development.

    Metzger JJ, Simunovic M, Brivanlou AH.

    Curr Opin Genet Dev. 2018 Oct;52:86-91. doi: 10.1016/j.gde.2018.06.006. Epub 2018 Jun 27. Review.

    PMID: 29957587

  14. WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids.

    Yoney A, Etoc F, Ruzo A, Carroll T, Metzger JJ, Martyn I, Li S, Kirst C, Siggia ED, Brivanlou AH.

    Elife. 2018 Oct 12;7. pii: e38279. doi: 10.7554/eLife.38279.

    PMID: 30311909

  15. Author Correction: Self-organization of a human organizer by combined Wnt and Nodal signalling.

    Martyn I, Kanno TY, Ruzo A, Siggia ED, Brivanlou AH.

    Nature. 2018 Dec;564(7735):E10. doi: 10.1038/s41586-018-0583-3.

    PMID: 30420607

  16. A wave of WNT signaling balanced by secreted inhibitors controls primitive streak formation in micropattern colonies of human embryonic stem cells.

    Martyn I, Brivanlou AH, Siggia ED.

    Development. 2019 Mar 25;146(6). pii: dev172791. doi: 10.1242/dev.172791.

    PMID: 30814117

  17. Chick Models and Human-Chick Organizer Grafts.

    Martyn I, Kanno TY, Brivanlou AH.

    Methods Mol Biol. 2019;2005:77-89. doi: 10.1007/978-1-4939-9524-0_6.

    PMID: 31175647

  18. Self-organizing neuruloids model developmental aspects of Huntington's disease in the ectodermal compartment.

    Haremaki T, Metzger JJ, Rito T, Ozair MZ, Etoc F, Brivanlou AH.

    Nat Biotechnol. 2019 Oct;37(10):1198-1208. doi: 10.1038/s41587-019-0237-5. Epub 2019 Sep 9.

    PMID: 31501559

  19. Mapping cell migrations and fates in a gastruloid model to the human primitive streak.

    Martyn I, Siggia ED, Brivanlou AH.

    Development. 2019 Sep 12;146(17). pii: dev179564. doi: 10.1242/dev.179564.

    PMID: 31427289

  20. A 3D model of a human epiblast reveals BMP4-driven symmetry breaking.

    Simunovic M, Metzger JJ, Etoc F, Yoney A, Ruzo A, Martyn I, Croft G, You DS, Brivanlou AH, Siggia ED.

    Nat Cell Biol. 2019 Jul;21(7):900-910. doi: 10.1038/s41556-019-0349-7. Epub 2019 Jul 1.

    PMID: 31263269

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