Technology

The Rumi Platform: Standardized Human Neural Tissues

Rumi’s technology is a powerful and versatile high-throughput organoid platform which mimics the development of the human nervous system, with fidelity and at high throughput.

We have an unprecedented ability to quantitatively identify differences between diseased and healthy human cells in a physiological environment. We are world leaders in human stem cell biology and the generation of brain cells in a region-specific manner. With our machine-learning algorithms, we conduct chemogenomic and genetic screens in organoids at a scale compatible with drug discovery.

Our capabilities enable the identification of potential therapeutics for neurodevelopmental and neurological conditions..

The Rumi Platform: Standardized Human Kidney Tissues

Rumi’s technology has been deployed to model the development of the human kidney, and generated models of toxicological injury and monogenic diseases affecting kidney function.

Our kidney mini-tissues enable the development of novel therapeutics for acute and chronic kidney disease, whether caused by metabolic syndrome or genetic diseases such as Alport or Poly-cystic kidney disease.

Breakthrough 1

The Human Model

We can mimic the development of the human tissues and the complex biology behind this process.

Rumi Scientific has fused stem cell biology and physics to create a transformative method of human embryonic stem cells which self-organize to generate a signature defined by geometry and size. Using cell lines with disease-causing mutations, Rumi can identify active therapeutics directly on disease models.

Breakthrough 2

Human Disease Models

We can mimic the development of a tissue of a person with a disease-causing mutation.

Rumi has utilized isogenic cell lines with the Huntington’s Disease mutation and identified a signature on Rumi’s Neuroloids. We have identified compounds capable of correcting the impact of the Huntington’s mutation on brain development.

Rumi has also generated disease models for neurodevelopmental, neurological and kidney disorders, fueling our internal pipeline.

rumi scientific_huntington disease control

Breakthrough 3

A High-throughput Platform

We can apply Breakthrough 1 and 2 in thousands of identical replicates.

Rumi Scientific’s proprietary technology has created a unique and transformative screening platform for genetic diseases to identify potential treatments. No other existing platform can achieve the qualitative and quantitative level of resolution obtained with our technology.

Breakthrough 4

Phenotypic Analysis using Artificial Intelligence

We can achieve unbiased analysis using deep neural networks to define disease signatures and deploy them to identify molecules with therapeutic potential.

Rumi’s technology deploys a micropattern technology as a new path to grow human embryonic stem cells. Human embryonic stem cells self-organize, replicating the physiological processes during embryonic development. By recapitulating the ongoing cell-to-cell signaling and studying the relationship between cells as they differentiate to give rise to different human cell types, Rumi’s technology can be applied to solve myriad problems in the drug discovery process.

The Rumi technology is the result of a decade-long cooperation by the heads of the Physics and Stem Cell Biology Laboratories at The Rockefeller University.

Numerous Advantages over Existing Processes

Rumi Scientific’s platform outperforms existing drug discovery technologies.
What we start with can become anything.

A high throughput platform to enable therapeutic discovery

A generation of human minituarized tissues at scale enables target identification & therapeutic development, as shown below

Cerebroid

Late Cerebroid

Neuruloid

Human Models + Isogenic Lines

Under 14% of drug development programs make it to Phase I. One reason for this low success rate is the lack of accurate and representative human models. Rumi's platform uses human embryonic stem cell lines that are genetically identical except for the gene causing the disease. As a result, our technology creates a better physiological disease model: Human isogenic lines allow us to accurately associate a phenotype with the gene edited, as all other genes remain the same.

Phenotypic Mining & Discovery

Rumi's platform reveals phenotypes which could not previously be found in high-throughput scteening against these phenotypes identifies hits to jumpstart the discovery process, unbiased with regard to pathway or target.

Unbiased AI-driven Analysis

Using proprietary AI-driven methodology, we are able to analyze our phenotypic data output without bias, and without relying on pre-determined phenotypes, thus better measuring the biological complexity of human tissues, and resulting in previously unseen Z' scores.

Universally Applicable

Rumi Scientific’s platform is disease-agnostic. The phenotypic characteristics are determined without bias by our machine learning algorithms, thus allowing the platform to extend to other diseases.

Specificity/Toxicity

Our unique quantification methods can additionally categorize compounds with respect to their toxicity/off-target effects and their therapeutic effect. This creates an information-rich pipeline that is necessary for the success of drug development.

Clinical Targets

The use of Rumi's platform for drug discovery is not only enables a more efficient discovery process of drug candidates, but also assists in the development of more efficient clinical strategies. As Rumi's models focus on drug effects for patients with a specific genetic fingerprint, future clinical trials could be designed to target patients with those genetic markers, which would allow for smaller, more targeted clinical trials and a faster development process.

Comparative Analysis: Pre-clinical Platforms

Rumi Scientific’s platform outperforms existing drug discovery technologies

	Rumi	2D Cell Models	3D Organoids	In Silico
Throughput
In Vivo Relevance				?
Analytical Tools
Standardization				n.a.
Broad Applicability

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